Advancing Biomedical Innovation in Oxidative Stress Management
Harnessing Diatomic Hydrogen to Eliminate Reperfusion Injury in Transplants and Surgery.
Diatomic is dedicated to developing safe, innovative therapies using diatomic hydrogen (H₂) to combat ischemia-reperfusion injury (IRI) in organ transplantation, cardiac surgery, and related fields.
The Problem
Ischemia-Reperfusion Injury: A Barrier to Successful Transplants
Ischemia-reperfusion injury (IRI) is a major cause of transplant failure and surgical complications. When blood returns to oxygen-deprived tissue, it triggers oxidative stress, inflammation, and organ dysfunction.
ALL transplanted organs are affected by reperfusion injury—even healthy ones
Marginal organs are severely impacted
62% of donated organs are scrapped, often because they cannot survive the stress of reperfusion injury
IRI limits donor organ usability, increases delayed graft function, and contributes to rejection.
Our Breakthrough
Diatomic Hydrogen Therapy: Selective, Safe, and Effective
Diatomic Inc. leverages the unique properties of diatomic hydrogen (H₂) to neutralize oxidative stress and protect organs during transplantation and surgery.
Selective Neutralization: H₂ targets only the most harmful reactive oxygen species (ROS), such as the hydroxyl radical (OH•)
High Permeability: The smallest molecule, H₂ diffuses rapidly to reach vulnerable intracellular injury targets like mitochondria
Anti-Inflammatory: Modulates NF-κB and reduces cytokine production
Anti-Apoptotic: Preserves cell integrity by regulating key proteins and blocking damage-amplifying signals
Safe: Non-toxic at high doses; also naturally produced in the human gut
H₂ can be delivered via dissolved solutions or our proprietary devices, achieving therapeutic concentrations quickly and efficiently.
Built on Evidence
Our intellectual property in formulation, storage, and hydrogen delivery solutions supports effective, targeted administration in clinical settings.
In preclinical studies, Diatomic preserved cardiac viability leading to perfect functionality after 7 hours of cold ischemia in porcine heart transplants.
In a kidney reperfusion injury model, reperfused pig kidneys treated with Diatomic Hydrogen showed 4-fold improvement in filtering function and 3-fold improvement in urine output compared to kidneys treated with the current standard of care.
“The current organ shortage has stimulated the use of marginal donors for transplantation… These drawbacks have created the greatest clinical challenge in transplantation to date.”
— Dr. Takehide Asano et al.
Contact Us
Diatomic welcomes inquiries from research partners, clinical institutions, and investors.